Inlet noise on 0.5-meter-diameter NASA QF-1 fan as measured in an unmodified compressor aerodynamic test facility and in an anechoic chamber

Narrowband analysis revealed grossly similar sound pressure level spectra in each facility. Blade passing frequency (BPF) noise and multiple pure tone (MPT) noise were superimposed on a broadband (BB) base noise. From one-third octave bandwidth sound power analyses the BPF noise (harmonics combined), and the MPT noise (harmonics combined, excepting BPF's) agreed between facilities within 1.5 db or less over the range of speeds and flows tested. Detailed noise and aerodynamic performance is also presented

Aerodynamic performance of 0.5 meter-diameter, 337 meter-per-second tip speed, 1.5 pressure-ratio, single-stage fan designed for low noise aircraft engines

Overall and blade-element aerodynamic performance of a 0.271-scale model of QF-1 are presented, examined, and then compared and evaluated with that from similar low noise fan stage designs. The tests cover a wide range of speeds and weight flows along with variations in stator setting angle and stator axial spacing from the rotor. At design speed with stator at design setting angle and a fixed distance between stage measuring stations, there were no significant effects of increasing the axial spacing between rotor stator from 1.0 to 3.5 rotor chords on stage overall pressure ratio, efficiency or stall margin

Redesign and cascade tests of a supercritical controlled diffusion stator blade-section

A supercritical stator blade section, previously tested in cascade, and characterized by a flat-roof-top suction surface Mach number distribution, has been redesigned and retested. At near design conditions, the losses and air turning were improved over the original blade by 50 percent and 7 percent respectively. The key element in the improved performance was a small blade reshaping. This produced a continuous flow acceleration over the first one-third chord of the suction surface which successfully prevented a premature laminar separation bubble. Several recently available inviscid analysis and one fully viscous (Navier-Stokes) analysis code were used in the redesign process. The validity of these codes was enhanced by the test results

Aerodynamic performances of three fan stator designs operating with rotor having tip speed of 337 meters per second and pressure ratio of 1.54. Relation of analytical code calculations to experimental performance

A hub-to-shroud and a blade-to-blade internal-flow analysis code, both inviscid and basically subsonic, were used to calculate the flow parameters within four stator-blade rows. The produced ratios of maximum suction-surface velocity to trailing-edge velocity correlated well in the midspan region, with the measured total-parameters over the minimum-loss to near stall operating range for all stators and speeds studied. The potential benefits of a blade designed with the aid of these flow analysis codes are illustrated by a proposed redesign of one of the four stators studied. An overall efficiency improvement of 1.6 points above the peak measured for that stator is predicted for the redesign

De patient bestaat niet

Rede, Uitgesproken bij aanvaarding van van het ambt van bijzonder hoogleraar met als leeropdracht klinische farmacologie aan het Erasmus MC, faculteit van de Erasmus Universiteit Rotterdam op 16 september 2011. De klinische farmacologie is de wetenschap die zich bezighoudt met het bestuderen van de toepassing van geneesmiddelen bij de mens. De basis wordt gevormd door kennis over de werkingsmechanismen van geneesmiddelen en de pathofysiologie van ziektebeelden. De klinische farmacologie verbindt als het ware de basale farmacologische principes met de klinische praktijk. Het uiteindelijke doel is het beter inzetten van geneesmiddelen bij de behandeling van patiënten, waarbij gestreefd wordt naar optimale effectiviteit en naar het beperken van bijwerkingen. De veronderstelling dat geneeskunde en farmacie hierbij gecombineerd worden is dus ook niet zo gek. Sterker nog, om de klinische farmacologie optimaal te benutten is een nauwe samenwerking tussen artsen en apothekers van groot belang

Phase of beta-frequency tACS over primary motor cortex modulates corticospinal excitability

The assessment of corticospinal excitability by means of transcranial magnetic stimulation-induced motor evoked potentials is an established diagnostic tool in neurophysiology and a widely used procedure in fundamental brain research. However, concern about low reliability of these measures has grown recently. One possible cause of high variability of MEPs under identical acquisition conditions could be the influence of oscillatory neuronal activity on corticospinal excitability. Based on research showing that transcranial alternating current stimulation can entrain neuronal oscillations we here test whether alpha or beta frequency tACS can influence corticospinal excitability in a phase-dependent manner. We applied tACS at individually calibrated alpha- and beta-band oscillation frequencies, or we applied sham tACS. Simultaneous single TMS pulses time locked to eight equidistant phases of the ongoing tACS signal evoked MEPs. To evaluate offline effects of stimulation frequency, MEP amplitudes were measured before and after tACS. To evaluate whether tACS influences MEP amplitude, we fitted one-cycle sinusoids to the average MEPs elicited at the different phase conditions of each tACS frequency. We found no frequency-specific offline effects of tACS. However, beta-frequency tACS modulation of MEPs was phase-dependent. Post hoc analyses suggested that this effect was specific to participants with low (<19 Hz) intrinsic beta frequency. In conclusion, by showing that beta tACS influences MEP amplitude in a phase-dependent manner, our results support a potential role attributed to neuronal oscillations in regulating corticospinal excitability. Moreover, our findings may be useful for the development of TMS protocols that improve the reliability of MEPs as a meaningful tool for research applications or for clinical monitoring and diagnosis. (C) 2018 Elsevier Ltd. All rights reserved

Aerodynamic performances of three fan stator designs operating with rotor having tip speed of 337 meters per second and pressure ratio of 1.54. 1: Experimental performance

The aerodynamic performances of four stator-blade rows are presented and evaluated. The aerodynamic designs of two of these stators were compromised to reduce noise, a third design was not. On a calculated operating line passing through the design point pressure ratio, the best stator had overall pressure-ratio and efficiency decrements of 0.031 and 0.044, respectively, providing a stage pressure ratio of 1.483 and efficiency of 0.865. The other stators showed some correctable deficiencies due partly to the design compromises for noise. In the end-wall regions blade-element losses were significantly less for the shortest chord studied

Comparison of climate and production in closed, semi-closed and open greenhouses

A (semi-)closed greenhouse is a novel greenhouse with an active cooling system and temporary heat storage in an aquifer. Air is cooled, heated and dehumidified by air treatment units. Climate in (semi-)closed greenhouses differs from that of conventional open greenhouses. The aims of our research were first, to analyze the effect of active cooling on greenhouse climate, in terms of stability, gradient and average levels; second, to determine crop growth and production in closed and semi-closed greenhouses. An experiment with tomato crop was conducted from December 2007 until November 2008 in a closed greenhouse with 700 W m-2 cooling capacity, two semi-closed greenhouses with 350 and 150 W m-2 cooling capacity, respectively, and an open greenhouse. The higher the cooling capacity, the more independent the greenhouse climate was of the outside climate. As the cooling ducts were placed underneath the plants, cooling led to a remarkable vertical temperature gradient. Under sunny conditions temperature could be 5°C higher at the top than at the bottom of the canopy in the closed greenhouse. Cumulative production in the semi-closed greenhouses with 350 and 150 W m-2 cooling capacity were 10% (61 kg m-2) and 6% (59 kg m-2) higher than that in the open greenhouse (55 kg m-2), respectively. Cumulative production in the closed greenhouse was 14% higher than in the open greenhouse in week 29 after planting but at the end of the experiment the cumulative increase was only 4% due to botrytis. Model calculations showed that the production increase in the closed and semi-closed greenhouses was explained by higher CO2 concentratio

First-Order Provenance Games

We propose a new model of provenance, based on a game-theoretic approach to query evaluation. First, we study games G in their own right, and ask how to explain that a position x in G is won, lost, or drawn. The resulting notion of game provenance is closely related to winning strategies, and excludes from provenance all "bad moves", i.e., those which unnecessarily allow the opponent to improve the outcome of a play. In this way, the value of a position is determined by its game provenance. We then define provenance games by viewing the evaluation of a first-order query as a game between two players who argue whether a tuple is in the query answer. For RA+ queries, we show that game provenance is equivalent to the most general semiring of provenance polynomials N[X]. Variants of our game yield other known semirings. However, unlike semiring provenance, game provenance also provides a "built-in" way to handle negation and thus to answer why-not questions: In (provenance) games, the reason why x is not won, is the same as why x is lost or drawn (the latter is possible for games with draws). Since first-order provenance games are draw-free, they yield a new provenance model that combines how- and why-not provenance